WebThe spectrum of hepatocellular proliferative lesions in B6C3F1 (C57BL/6N × C3H/HeN MTV-) mice used in National Toxicology Program (NTP) two-year carcinogenicity studies includes foci of cellular alteration, adenoma, carcinoma, and hepatoblastoma. WebSistare et al. further evaluated the predictivity of histopathological findings, considering risk factors for rat neoplasia (hypertrophy, hyperplasia, metaplasia, cell proliferation, foci of cellular alteration, and inflammation accompanied by recurrent cell necrosis and repair) that were observed microscopically in 6-month rat toxicity studies ...
Liver - Focus - Nonneoplastic Lesion Atlas - National …
WebWatanabe K, Williams GM (1978) Enhancement of rat hepatocellular-altered foci by the liver tumor promoter phenobarbital: evidence that foci are precursors of neoplasms and that … WebSep 4, 2008 · On the other hand, hepatic lesions (foci of cellular alteration) are manifested only after a lag of more than 6 months (Nagazawa et al. 1985, Vethaak and Jol 1996). Therefore, the field situation observed in winter 2006 had developed months before, when river runoff was at its lowest level. Furthermore, the better fish health conditions ... palmopercusion pulmonar
Alterations in cytoskeletal and Ca2+ cycling regulators in atria ...
WebTo examine the effect of ethanol on hepatocarcinogenesis induced by a choline-deficient, ethionine-supplemented (CDE) diet, rats were fed either an ethanol-supplemented diet or ethanol-free, isocaloric diet for 2 months, followed by a CDE diet or control diet for up to 8 months. Changes to cellular … WebJan 1, 2003 · Lesions were classified as foci of cellular alteration smaller than one liver lobule (altered hepatic foci; AHF), foci of cellular alteration larger than one liver lobule (large foci of cellular alteration; LFCA), adenomas (ADs), or carcinomas (CAs). Histopathologic analysis of 598 premalignant lesions revealed that (a)) each lesion class … WebAll AHF observed could be classified as basophilic, eosinophilic, clear, vacuolated, or mixed types using criteria applied previously to the Fischer-344 (F-344) rat. Some eosinophilic … エクセル グラフ 滝