WebJan 18, 2024 · The TFs interferon regulatory factor 3 (IRF3), IRF5 and IRF7 (IRF3/5/7) ... To understand the role of DNA binding in IFN regulation, we mapped the binding of IRF3/5/7 dimers to all human and mouse IFN gene VREs. We found that IRF3 and IRF7 bind across many of the VRE sub-elements, but that the VRE-A/B sub-element is bound almost … WebApr 13, 2024 · Knockdown of STING (stimulator of interferon genes), TBK1 (TANK-binding kinase-1), or IRF3 (interferon regulatory factor-3) also resulted in increased micronuclei formation.
Irf3 MGI Mouse Gene Detail - MGI:1859179 - interferon …
WebDuring infection, IRF-3 is likely activated through a pathway that includes activation of Toll-like receptors and a kinase complex that includes IKKε and TBK1 (6,7). IRF-3 is … WebWe uncovered a general mechanism of IRF3 activation by the innate immune adaptor proteins MAVS, STING, and TRIF, which functions in three distinct pattern recognition pathways. Following its activation, each adaptor protein recruits and activates downstream kinase TBK1, which phosphorylates the cognate upstream adaptor protein at a consensus … florida manatee mating season
IRF3 inhibits nuclear translocation of NF-κB to prevent viral ...
WebE. coli -derived recombinant mouse IRF3 Thr201-Ile419 Accession # P70671 Formulation Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is … WebHere we examined the role of IRF3 in expression of innate anti-viral proteins produced in response to IFN-γ plus TLR3 agonist. Wild-type (WT) and IRF3KO RAW264.7 cells, each with ISG54-promoter-luciferase reporter vectors, were stimulated with IFN-γ, poly I:C, or both together. ISG54 promoter activity was significantly reduced in IRF3KO ... WebMay 5, 2024 · The nuclear translocation of activated IRF3 leads to the transcriptional upregulation of type I interferons and pro-inflammatory cytokines 2, 19, 20. An essential role for cGAS is its capacity to... greatway locations