WebAug 6, 2008 · Purpose Determine the toxicity, maximum tolerated dose (MTD), and pharmacokinetics of paclitaxel poliglumex (PPX; CT-2103) in combination with cisplatin … WebOct 9, 2024 · Paclitaxel poliglumex (PPX) is macromolecular drug conjugate that links paclitaxel with a biodegradable polymer, poly-L-glutamic acid. PPX enhances tumor exposure by taking advantage of the hyperpermeable vasculature and suppressed lymphatic clearance characteristic of tumor tissue.

Paclitaxel poliglumex for ovarian cancer - Taylor & Francis

WebDescribed herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of a Weba.TAXOL (PACLITAXEL) administered intravenously over 3 hours at a dose of 175 mg/m2 followed by cisplatin at a dose of 75 mg/m2; or b.TAXOL (PACLITAXEL) administered intravenously over 24 hours at a dose of 135 mg/m2 followed by cisplatin at a dose of 75 mg/m2 2) In patients previously treated with chemotherapy for carcinoma of the ovary, … arma g36 hk

Cell Therapeutics Announces GOG Completes Patient …

WebPaclitaxel poliglumex (PPX) is a recently developed taxane in which paclitaxel is conjugated to poly (l-glutamic acid), which renders it water soluble, reduces … WebJun 6, 2011 · OPAXIO (TM) (paclitaxel poliglumex, CT-2103), which was formerly known as XYOTAX (TM), is an investigational, biologically enhanced, chemotherapeutic that … WebJul 1, 2008 · Paclitaxel poliglumex (PPX) is a conjugate that links paclitaxel to a biodegradable polymeric backbone consisting of l-glutamic acid residues. 14 PPX is … arma g2c taurus